Tripeptide derivatives for the treatment of neurod

专利名称：Tripeptide derivatives for the treatment of

neurodegenerative diseases

发明人：Jean Rapin,Hans Klaus Witzmann,Jean-Marie

Grumel,Jacques Gonella

申请号：US10635696申请日：20030805

公开号：US20050192228A1公开日：20050901

摘要：The invention relates to the use of specific tripeptides for the treatment ofneurodegenerative diseases. The tripeptide derivatives satisfy the following formula (I):wherein X represents OH, (C)alkoxy, NH, NH—C-alkyl, N(Calkyl); Ris a residue derivedfrom any of the amino acids Phe, Tyr, Trp, Pro, each of which may optionally be

substituted by a (C)alkoxy group, a (C)alkyl group or a halogen atom, and Ala, Val, Leu, orIle; Ris a residue which is derived from any of the amino acids Gly, Ala, Ile, Val, Ser, Thr, His,Arg, Lys, Pro, Glu, Gln, pGlu, Asp, Leu and Asn; Rand Rindependently represent H, OH,(C)alkyl, or (C)alkoxy, provided that Rand Rare not both OH or (C)alkoxy; Rrepresents H,OH, (C)alkyl or (C)alkoxy; and wherein Rpreferably represents a cinnamoyl residue; orpharmaceutically acceptable salts thereof.

申请人：Jean Rapin,Hans Klaus Witzmann,Jean-Marie Grumel,Jacques Gonella

地址：Paris FR,Egglkofen DE,Tassin la Demi-Lune FR,Muttenz CH

国籍：FR,DE,FR,CH

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