Compositions and methods for detecting ligand-depe

专利名称：Compositions and methods for detecting

ligand-dependent nuclear receptor andcoactivator interactions

发明人：Jeffrey P. Northrop,Charles P. Hart,Peter J.

Schatz

申请号：US09053611申请日：19980401公开号：US010245B1公开日：20020625

摘要：The invention provides methods for identifying agents that are ligands fornuclear receptors. The methods include conducting multiplexed assays utilizing positivehybrid systems, reverse hybrid systems, direct interaction assays and other assays toscreen for ligands having activity with a receptor of interest. The methods can beperformed in various multiplexing formats to produce a profile that can be used tocategorize a test ligand relative to known agonists and antagonists.

申请人：AFFYMAX, INC.

代理机构：Townsend and Townsend and Crew LLP

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