Plasminogen activator to prevent corneal and subep

专利名称：Plasminogen activator to prevent corneal

and subepithelial haze after laser visioncorrection surgery

发明人：David M. Silver,Adrienne Csutak,Andras

Berta,Jozsef Tozser

申请号：US10398677申请日：20030409

公开号：US20040001821A1公开日：20040101

专利附图：

摘要：The present invention is directed to a method to prevent or reduce

postoperative corneal subepithelial haze after excimer laser photorefractive

keratectomy (PRK), laser in situ keratomileusis (LASIK) surgery. According to the method,a therapeutically effective amount of one or more plasminogen activators, most

preferably urokinase (uPA), is administered topically to the surface of the affected eye atlevels between 0.1 and 2,500 IU/ml, about eight to twelve times on the day of surgery,and four to eight times per day for about the next six to twelve days thereafter. Themost preferred therapeutic amount is from about 0.1-1 IU uPA/ml, and also 1-10 IU/ml.Plasminogen activators that can be used in the inventions include urokinase,

prourokinase, tissue plasminogen activator, streptokinase and mutants thereof. Theinvention also covers topical ophthalmic compositions that include one or moreplasminogen activators, most preferably uPA, to prevent or reduce postoperativecorneal subepithelial haze.

申请人：SILVER DAVID M.,CSUTAK ADRIENNE,BERTA ANDRAS,TOZSER JOZSEF

更多信息请下载全文后查看