METHODS, COMPOSITIONS AND KITS FOR CELL SPECIFIC M

专利名称：METHODS, COMPOSITIONS AND KITS FOR

CELL SPECIFIC MODULATION OF TARGETANTIGENS

发明人：Jesper GROMADA,Eric SMITH,Andrew

MURPHY,Nicholas PAPADOPOULOS,JoelMARTIN,George YANCOPOULOS,DouglasMACDONALD,David BUCKLER

申请号：US15119986申请日：20150220

公开号：US20170058045A1公开日：20170302

摘要：The present invention provides, inter alia, a method for cell-specific modulationof a target antigen. The method comprises contacting a target cell having the targetantigen on the surface of the target cell with: (a) first multi-specific antigen-bindingpolypeptide comprising: (i) a cell-specific antigen binding domain (C1), (ii) a target antigenbinding domain (T1); and (b) a second multi-specific antigen-binding polypeptidecomprising: (i) a cell-specific antigen binding domain (C2), (ii) a target antigen bindingdomain (T2); wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. Pharmaceuticalcompositions and kits thereof are also included in the present invention.

申请人：Regeneron Pharmaceuticals, Inc.

地址：Tarrytown NY US

国籍：US

更多信息请下载全文后查看