ANTIVIZAL DIBENZOTHIAZEPINONE DERIVATIVES

专利名称：ANTIVIZAL DIBENZOTHIAZEPINONE

DERIVATIVES

发明人：ROBIN HAMISH NICOL,MARTIN JOHN

SLATER,SIMON TEANBY HODGSON

申请号：AU1655192申请日：19920501公开号：AU1655192A公开日：19921221

摘要：PCT No. PCT/GB92/00805 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6,1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19277 PCT Pub. Date Nov. 12, 1992 (I)Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same ordifferent, each represent one or more ring substituent(s) selected from: hydrogen,hydroxy, halogen, cyano, nitro, C1-6alkyl, C3-6cycloalkyl or C1-6alkoxy (where the alkylor cycloalkyl moiety may be optionally substituted by one or more substituents selectedfrom halogen atoms and hydroxyl groups); -NR4R5 where R4 and R5, which may be thesame or different, each represent hydrogen or C1-6alkyl; -S(O)mR6, where m is 0, 1, 2 or 3and R6 represents hydrogen, C1-6alkyl or C3-6cycloakyl; -SO2NR4R5 where R4 et R5 areeach as defined above; phenyl, phenylC1-3alkoxy or phenylC1-3alkyl where the phenylgroup may be optionally substituted by one or more substituents independentlyselected from C1-6alkyl, C1-6alkoxy, hydroxy, nitro, halogen and amino; and -CO2H or -COR7 where R7 is C1-6alkyl or C3-6cycloalkyl; R3 represents hydrogen or C1-4alkyl; andesters, salts and other physiologically functional derivatives thereof; show activity asantiviral agents, for example against HIV. Certain of the compounds are novel.

申请人：THE WELLCOME FOUNDATION LIMITED

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